The process of purchase psilocybin can be intimidating for first-timers, but it’s important to do your research and choose a reputable vendor. Look for a vendor with a solid reputation within the mushroom community, and browse online communities such as Shroomery and r/shrooms to read reviews and testimonials. It’s also a good idea to find a chaperone—also known as a trip sitter—to accompany you during your experience, especially if you’re a first-timer.

Unlike antidepressants, which take weeks to work, psilocybin can improve mood in just one or two sessions. It attaches to receptors in the brain to increase serotonin, a chemical that promotes feelings of well-being.

How is Oregon’s legalization of psilocybin different from our legalization of marijuana

Researchers are investigating the effects of psilocybin on depression, addiction, and anxiety. In a recent study, people with treatment-resistant depression who received psilocybin experienced meaningful spiritual experiences during their session, and the effect lasted for a month. The drug may also help reduce alcohol use, as those who were given psilocybin engaged in less heavy drinking and experienced fewer withdrawal symptoms than those who took a placebo.

If a practitioner wishes to purchase psilocybin, they must apply to the Special Access Program for an authorization letter. The application is assessed on a case-by-case basis, taking into account the level of evidence regarding the safety and efficacy of the drug and the proposed use. If approved, the practitioner will be provided with a manufacturer’s name and address so that they can order psilocybin. The manufacturer will be required to comply with the conditions set out in the Guidance Document for Industry and Practitioners.